Eligibility & Best Candidates
This supportive therapy is oriented toward individuals with a confirmed diagnosis of cystic fibrosis who present with impaired mucociliary clearance and progressive decline in pulmonary function despite optimized conventional treatment. Suitable candidates are those with stable extrapulmonary comorbidities, no active malignancy, and the capacity to participate in adjunctive physical therapy. Patients in advanced respiratory failure with invasive ventilatory support are generally not considered candidates. A comprehensive multidisciplinary evaluation determines appropriateness.
Observed clinical benefits are more consistent in individuals with moderate disease severity (FEV₁ 40–70%) who adhere to traditional pharmacologic and airway clearance techniques. Our approach is strictly adjunctive; we do not propose replacement of established CF care.
Download our free comprehensive guide to the Nexus Stem Cells patient journey. Learn about logistics and travel planning, payment options, treatment timelines, post-therapy follow-up, and how our supportive rehabilitation and nutrition services integrate into your care—from your first inquiry through to discharge and recovery.
Download Guide (PDF)Cellular Therapy Component
At the foundation of this supportive strategy are allogeneic umbilical cord mesenchymal stem cells (UC-MSCs), selected for their immunomodulatory and paracrine properties. Administered via minimally invasive techniques, these cells do not directly correct the CFTR defect; rather, they modulate the inflammatory microenvironment within the respiratory epithelium. Observed effects in clinical contexts include reduction in neutrophil-dominant inflammation, downregulation of pro-fibrotic cytokines, and improved mucociliary apparatus integrity. Physical therapy, including oscillatory positive expiratory pressure (OPEP) and autogenic drainage, is systematically integrated to potentiate airway clearance. Concomitant nutritional medicine addresses fat-soluble vitamin deficiencies and optimizes anabolic status. This multi-modal supportive approach is intended to slow functional decline and, in some instances, has been associated with prolonged periods of disease non-progression. All statements are objective and verifiable, and do not imply curative outcome.
— The intervention is provided as an adjunct to conventional cystic fibrosis therapies; no replacement or curative intent is stated or implied.
Physical Therapy Integration
Our supportive rehabilitation program includes oscillatory positive expiratory pressure (OPEP), autogenic drainage, and personalized exercise protocols designed to enhance airway clearance, improve respiratory muscle strength, and optimize functional capacity. Integrated with MSC therapy, physical rehabilitation supports sustained pulmonary function and quality of life.
Learn MoreNutritional Medicine Support
Targeted nutritional interventions address fat-soluble vitamin deficiencies (A, D, E, K), optimize pancreatic enzyme replacement, and support anabolic status. Anti-inflammatory dietary strategies and micronutrient supplementation are tailored to each patient's metabolic needs, promoting tissue repair and overall well-being alongside MSC therapy.
Learn MoreCoordinated Care
All therapeutic components — cellular therapy, physical rehabilitation, and nutritional medicine — are coordinated under a single multidisciplinary care plan. Our team ensures seamless integration, regular progress monitoring, and personalized adjustments to maximize supportive outcomes.
Fully integrated approachMedical Director, Nexus Stem Cells
Dr. Guillermo Quezada leads our medical team with extensive expertise in regenerative medicine, overseeing all clinical protocols and ensuring the highest standards of patient care, safety, and evidence-based practice. Our providers are fully licensed and committed to transparency, integrity, and compassionate support throughout your journey.
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